International Review of Ophthalmology ›› 2023, Vol. 47 ›› Issue (1): 47-52.doi: 10.3760/ cma.j.issn.1673-5803.2023.01.009

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Progress on treatment of fungal keratitis with nano preparation improved antifungal drugs

Huang Yue，Li Yan，Li Yuting，Bao Zheng Yilin，Yu Yongyuan，Hu Zhulin   

  1. Department of Ophthalmology, Affiliated Hospital of Yunnan University; The Second People’s Hospital of Yunnan Province; Yunnan Eye Hospital; Fourth Affiliated Hospital of Kunming Medical University; Yunnan Eye Institute; Yunnan Clinical Medical Research Center of Eye Diseases; Yunnan Clinical Medical Center of Eye Diseases; Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology, Kunming 650021, China
  • Received:2022-05-24 Online:2023-02-22 Published:2023-03-11
  • Contact: Hu Zhulin, Email: hzl77@263.net E-mail:hzl77@263.net
  • Supported by:
    Association Foundation Program of Yunnan Province Science and Technology Department and Kunming Medical University (202001AY070001-165); Yunnan Provincial Health Commission Medical Leading Talents Training Plan（L-2019029）；Yunnan Basic Research Project（202201AT070073）

Abstract: Fungal keratitis is an eye disease that seriously damages vision. At present, anti-fungal eye drops are the main methods to treat fungal keratitis. However, due to the short contact time between anti-fungal eye drops and eye surface, and poor corneal permeability, eye drops are needed to used frequently to maintain the therapeutic concentration of drugs. Frequent topical use of eye drops may be associated with side effects such as congestion and delayed corneal reepithelialization. In recent years, nanomaterials have been found to be a good eye delivery system, which can effectively improve the bioavailability of eye drops and reduce the frequency of eye drops. (Int Rev Ophthalmol, 2023, 47: 47-52)

Key words: nano preparation, antifungal drugs, fungal keratitis